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Por favor use este identificador para citar o enlazar este item:
http://hdl.handle.net/2250/6417
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| Título : | Topical anti-inflammatory activity of 2 alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae |
| Autores : | Aguirre, María C.
Delporte Vergara, Carla
Backhouse Erazo, Nadine
Erazo, Silvia
Letelier, María Eugenia
Cassels Niven, Bruce K.
Silva, X.
Alegría, S.
Negrete, Rosa |
| Palabras Clave : | Ugni molinae
Asiatic acid
Corosolic acid
Alphitolic acid
Anti-inflammatory activity-triterpenoids
URSOLIC ACID
OLEANOLIC ACID
APOPTOSIS
KINASE |
| Fecha de Publicación : | 15-ago-2006 |
| Editor : | PERGAMON-ELSEVIER SCIENCE LTD |
| Cita : | BIOORGANIC & MEDICINAL CHEMISTRY 14(16):5673-5677 |
| Resumen : | Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2 alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. |
| URI : | http://hdl.handle.net/2250/6417 |
| ISSN : | 0968-0896 |
| Aparece en Colecciones : | Artículos de revistas
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