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http://hdl.handle.net/2250/6416
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| Título : | Analgesic activity of Ugni molinae (murtilla) in mice models of acute pain |
| Autores : | Delporte Vergara, Carla
Backhouse Erazo, Nadine
Inostroza, V.
Aguirre, María C.
Peredo, N.
Silva, X.
Negrete, Rosa
Miranda, Hugo |
| Palabras Clave : | Ugni molinae
Analgesic activity triterpenoids
Myrtaceae
NONSTEROIDAL ANTIINFLAMMATORY DRUGS
URSOLIC ACID
OLEANOLIC ACID
FLAVONOIDS
ANTINOCICEPTIVE ACTION |
| Fecha de Publicación : | 30-may-2007 |
| Editor : | ELSEVIER IRELAND LTD |
| Cita : | JOURNAL OF ETHNOPHARMACOLOGY 112(1):162-165, may 30 2007. |
| Resumen : | Leaf extracts of Ugni molinae Turcz. (Myrtaceae) are used in Chilean folk medicine as analgesic and anti-inflammatory. The antinociceptive effect of dichloromethane (I)CM), ethyl acetate (EA) and methanol (ME) leaf extracts was assessed by intraperitoneal, oral and topical administration in writhing, tail flick, and tail formalin tests in mice.
The extracts showed a dose-dependent antinociceptive activity in all the assays under different administration routes. The EC50 values for the different tests for the DCM, EA, ME extract and reference drug (ibuprofen) were as follows. Writhing test in acetic acid (i.p. administration): 0.21, 0.37, 1.37 and 0.85 mg/kg, respectively; tail flick test (oral administration): 199, 189, 120 and 45.9 mg/kg. The EC50 values for tail flick test were (topical administration): 2.0, 0.35, 1.4 and 8.2% (w/v), respectively; and the topical analgesic effects were (formalin assay) 75.5, 77.5, 31.6 and 76.5%, respectively.
Ugni molinae extracts produce antinociception in chemical and thermal pain models through a mechanism partially linked to either lipooxygenase and/or cyclooxygenase via the arachidonic acid cascade and/or opioid receptors. Flavonoid glycosides and triterpenoids have been isolated from the plant and can be associated with the observed effect. Our results corroborate the analgesic effects of Ugni molinae, and justify its traditional use for treating pain. |
| URI : | http://hdl.handle.net/2250/6416 |
| ISSN : | 0378-8741 |
| Aparece en Colecciones : | Artículos de revistas
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